Can I run both SketchUp and LayOut at the same time?

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Yes, you can run both SketchUp and LayOut at the same time. In fact, you'll probably find many cases while working on a SketchUp model in LayOut when you'll need to open the model with SketchUp in order to edit it in ways that are beyond the scope of LayOut.

Note for SketchUp Pro network license users: Since LayOut is a feature of SketchUp Pro, you only use one seat of a network license when you are running both at the same time.